Amazonian shamans figured out that combining two specific plants out of 80,000 species produces a psychoactive effect. The odds of finding that combination by random search is roughly 1 in 4 million. They did it through centuries of iterative testing and cultural natural selection explains it

    by tractorboynyc

    37 Comments

    1. johnnydough10102223 on

      I think you underestimate the time course we are talking about here. With enough time and curiosity (or boredom) things can be discovered.

      Also: needs citation.

    2. MajorlyCynical on

      I always like to think what the first person who figured it out felt like. Like maybe they were just hungry trying to cook some kind of soup, next minute they are in a different dimension like wtf just happened.

    3. CrackheadMurderer on

      i wonder if there was a designated guy in the village they tested stuff on like “hey jerry try our weird new goop batch we just cooked up”

    4. I mean there were a good amount of people there for a good amount of time. I can see the coincidence being plausible. Only takes one guy trying out a new tea combo to realize there are extra dimensional beings

    5. Did they stop there? What if there’s something even better? The sky’s the limit! At least until you discover something that gets you even higher!

    6. Except both are individually active are they not? It’s just that the combined effect is far greater than each in their own.

      That’s a far simpler problem.

    7. Swords_and_Words on

      They also could watch local wildlife using it

      e.g. in south america, jaguars chew roots with psychedelic effects to get buzzed

    8. Educational_Lime_710 on

      Or it wasnt so random theres lots of animals in our world that use plants or other animals to get high like in the Amazon Jaguars that chew the bark and roots of specific plants to get high.

    9. Smooth-Duck-Criminal on

      AFAIK this is complete folklore, you can make Aya thousands of different ways much like beer. You don’t need those exact two plants. You can find DMT in many sources and you can find maoi inhibitors in many sources. Different cultures just swap in what’s locally available. Eg in desert regions it’s acacia seeds and Syrian rue.

      Even within the Amazon basin different plants are used giving different “flavors”. Over time, tribes have gone back to the best pairings with the highest concentrations.

    10. LeavesInsults1291 on

      Shout out to Amazonian shamans… took centuries for them to find out how to get us high as fuck. Legends.

    11. THENTHEHENHE on

      # They did it through centuries of iterative testing and cultural natural selection plus they had nothing better to do.

    12. Weird argument for me, are all 80k species stuff they regularly eat and mix? Also nature is not a vacuum, they probably saw some birds or other animals fucked up and tried to understand what they are etc, I don’t think this is particularly crazy

    13. “They did it through centuries of iterative testing and cultural natural selection explains it”

      Odd I could have sworn when asked they tell you that the plants themselves told them how to make it. But sure, you tell yourself that.

    14. unknownpoltroon on

      Imagine how many discoveries were lost between colonization and the church wiping out local knowledge.

    15. BrotherBringTheSun on

      The part that most people miss is that the MAO inhibitor plant, likely would have been known to make certain other plant medicines stronger. So it was only a matter of time that someone tried the ayahuasca plant with the “other plant that makes things stronger”

    16. It’s always mind blowing to me how indigenous tribes made all their discoveries when the only ones I know are from the grocery store.

    17. Dangerous-Train-8311 on

      Don’t worry, AI would have found it in a fraction of the time they did. And yes AI already did it, and then antibiotic candidate AI found is called Halicin. AI screened over 100 million molecules in 3 days and found it.

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